Global assembling of Academicians, Researchers, Scholars & Industry to disseminate and exchange information at 100+ Allied Academics Conferences

Peking University Six Hospital, China
Title: A Novel CYP7A1 Polymorphism is Associated With the Low-Density Lipoprotein Cholesterol Response to Atorvastatin
Biography

Miss Jing Chen completed her Master’s degree in Epidemiology and Hygenic statistics from School of Public Health, Peking University Health Science Center in 2016. She participated in a research study at Shi Mao Group Charity Hospital Research as an investigator. Her other research experiences include- National Free Preconception Health Examinaton Project (NFPHEP) during, The Family Based Cohort Study on The Common Non-communicable Chronic Diseases of the Population in The Rural Community of Northern China during and WHO project on “To promote the quality of Chinese maternal and child health annual report research”.

Abstract

Backgrounds and aims. Cholesterol 7? hydroxylase encoding by gene CYP7A1 is the initial and rate-limiting step in the classical bile acid synthesis pathway. Atorvastatin can markedly upregulate the mRNAs of bile acids synthetic enzymes CYP7A1 in the liver to increase fecal bile acid excretion. We tempt to investigate the association between a novel CYP7A1 polymorphism rs8192875 and reduction of lipid levels response to atorvastatin in Chinese patients with coronary artery disease. Methods. Of 169 patients with coronary artery disease were treated with atorvastatin for one month. Lipid profiles, including triglycerides(TGs), total cholesterol(TC), low-density lipoprotein cholesterol(LDL-C), and high-density lipoprotein cholesterol(HDL-C) were determined before and after treatment. Rs8192875 genotypes were assayed with the iPLEX assay in conjunction with the MassARRAY platform. We performed independent sample t test or Kruskal-Wallis test to evaluate the effects of SNP. Results. After one month of atorvastatin therapy, the lipid levels decreased significantly. Compared with AG genotype, the GG genotype of rs8192875 achieved a greater reduction of LDL-C level (0.694±0.701 vs. 0.136±0.401 mmol/l, p=0.0056; 24.090±23.104% vs. 2.182±20.809%, p=0.0031); and a similar pattern of efficacy appears to TC (0.808±0.791 vs. 0.302±0.381 mmol/l, p=0.0208; 16.410±15.370% vs. 6.936±9.711%, p=0.0341).The genotypes had no significant difference on TGs or HDL cholesterol-lowering response to atorvastatin. Conclusions. A novel CYP7A1 exon variant rs8192875 is significantly associated with reducing LDL-C and TC level response to atorvastatin. Keywords: Pharmacogenetics; CYP7A1; Atovarstatin; Lipid-lowing

Allied Academies Global Conference Directory

Mail us at

Program enquiry
heartdiseases@alliedconferences.org
Sponsors / Exhibiting / Advertising
heartdiseases@alliedconferences.com
General Queries
heartdiseases@alliedconferences.org
More details about sponsorship:sponsors@alliedacademies.com

Terms and Conditions

Responsibility

Delegates are personally responsible for their belongings at the venue. The Organizers will not be held responsible for any stolen or missing items belonging to Delegates, Speakers or Attendees; due to any reason whatsoever.

Insurance

Registration fees do not include insurance of any kind.

Transportation

Please note that any (or) all transportation and parking is the responsibility of the registrant.

Press/Media

Press permission must be obtained from Allied Academies Conferences Organizing Committee prior to the event. The press will not quote speakers or delegates unless they have obtained their approval in writing. The Allied Academies is an objective third-party non-profit organization. This conference is not associated with any commercial meeting company.

Requesting an Invitation Letter

For security purposes, letter of invitation will be sent only to those individuals who had registered for the conference. Once your registration is complete, please contact heartdiseases@alliedconferences.org to request a personalized letter of invitation.

Regarding refunds, all bank charges will be for the registrants account.

This cancellation policy was last updated on November 25, 2016.

Authorization Policy


Copyright © 2018-2019 Allied Academies, All Rights Reserved.