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Dr. Xiang Quanyong, Professor of Nanjing Medical University, Southeast University, is now working in the Department of Chronic non-communicable Disease Control and Prevention, Jiangsu Province Center for Disease Control and Prevention, China, deputy director of the department. He is a member of Chinese Hypertension Federation. His current main research activities are: 1) monitoring and analyzing of the prevalence of cardiovascular and cerebrovascular diseases, especially the control and prevention of Hypertension; 2) Diabetes control and prevention; 3) control and prevention of the risk factors for non-communicable disease, especially for Tobacco Control. He has published several papers in International Journal, Such as: Arch Toxicol, J Hum Genet, Oncotarget, J Diabetes Res, and so on.
Objectives: To explore the association between the AQP7, AQP9 genes polymorphisms in patients with hypertension and the risk of stroke in Chinese; and the possible gene-gene and gene-environment interactions. Methods: The stroke cases and the patients with hypertension were recruited from the follow-up cohort study of hypertension which established in 2010 in Jiangsu Province. The patients with stroke for the first time during the past 6 years were the cases groups, the patients with hypertension were the control groups which were chosen according to the inclusion criteria (paired with each stroke case): same gender, the age between ±3 years, the same place of residence, and the rate of case and control was 1:3. Genotyping of 5 SNPs in AQP7 (rs2989924, rs3758269, rs2542743) and AQP9 (rs57139208, rs16939881) was performed by the polymerase chain reaction assay. Results: The results of single SNP analysis showed that rs2989924 was associated with the risk of stroke in this case-control study, the frequency distribution was statistically significant; compared to AA+AG genotype, GG genotype significantly increased the risk of stroke, with an adjusted OR of 1.741(95% CI: 1.232-2.461). After adjusted confounders, CC+TT genotype of rs3758269 can be decreased the risk of stroke, with an adjusted OR of 0.669 (95% CI: 0.450-0.994), compared to CC genotype. Based on the stratified analysis, recessive genotype model of rs2989924 significantly increase the risk of stroke in male, over 60 years old, BMI(kg/m2)?25, and central obesity in hypertension patients, with an adjusted OR of 2.23 ? 95% CI:1.32-3.77?, 2.20?95% CI:1.41-3.44?,2.35(95% CI:1.45-3.81) and 1.81(95% CI:1.22-2.70). Before adjusted confounders rs3758269 has nothing to do with the stroke, but after adjusted confounders, rs3758269 was associated with decreased risk of stroke in over 60 years old and BMI(kg/m2)?25, with an adjusted OR of 0.48?95% CI:0.25-0.94?and 0.43(95% CI:0.24-0.77) in dominant genotype model. No gene-gene interaction and linkage disequilibrium were observed. Conclusions: SNPs rs2989924, rs3758269 were associated with the risk of stroke in Chinese Han population. No association between rs2542743, rs57139208, rs16939881 and the risk of stroke was found. Keywords: High blood pressure?Stroke?Aquaglyceroporin?genetic variants